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Methyl isopropyl ketone (MIPK)
Methyl isopropyl ketone (MIPK), also known as 3-methyl-2-butanone, is a branched aliphatic ketone belonging to the family of medium-boiling solvents. It is a clear, colorless, highly flammable liquid with an acetone-like odor. Because of its strong solvency power, balanced evaporation rate, and compatibility with numerous organic substances, it has become an important industrial solvent for coatings, adhesives, inks, cleaning products, and chemical syntheses.
MIPK is obtained through chemical processes such as catalytic oxidation or condensation reactions starting from suitable C5 hydrocarbons. It is less common in bulk production compared to acetone or methyl ethyl ketone, but is prized in applications that require a solvent with intermediate volatility and specific solubilizing properties.
In the coatings and printing industry, MIPK is widely used for lacquers, varnishes, and nitrocellulose-based systems, where it ensures strong solubilization of resins and controlled drying behavior. In the pharmaceutical sector, it serves as a process solvent in active ingredient synthesis and as an extraction medium for intermediates, subject to strict regulatory limits on residual solvents. In the agrochemical industry, MIPK is employed as a carrier solvent in crop protection formulations and as a process solvent for pesticide and herbicide intermediates. It is also used in adhesives, rubber processing, and cleaning agents, particularly for metal surfaces.
At PENPET, we supply methyl isopropyl ketone of consistent industrial quality, ensuring reliable performance in critical processes. The solvent is delivered in 165 kg new drums on pallets, allowing safe and efficient handling, storage, and transport.
CAS No.: 563-80-4
EC (EINECS) No.: 209-264-3
Molecular formula: C₅H₁₀O
Synonyms: Isopropyl methyl ketone, 3-methyl-2-butanone, 2-acetylpropane, MIPK
Areas of application: Solvent for coatings, lacquers, varnishes, adhesives, and printing inks; Extraction and process solvent in pharmaceutical synthesis; Carrier solvent and intermediate in agrochemical formulations; Cleaning agents, degreasers, and surface treatment solutions; Auxiliary in rubber and resin processing.
More Information
MIPK is a ketone with the structural formula CH₃–CO–CH(CH₃)₂. Its carbonyl group provides polarity and high solvency, while the isopropyl side group influences its volatility and evaporation rate, making it less volatile than acetone but faster drying than higher ketones.
Physical and chemical properties
Methyl isopropyl ketone is a clear, colorless liquid with an acetone-like, mildly sweet odor. It has a density of about 0.80 to 0.81 g/cm³ at 20 °C and a boiling point in the range of 92 to 94 °C. The substance has a very low melting point of approximately −92 °C and a vapor pressure of around 8.6 kPa at 20 °C. With a flash point of about 5 °C (closed cup) and an auto-ignition temperature near 475 °C, it is classified as a highly flammable liquid. MIPK is only partly soluble in water, with a solubility of 6 to 8 g/L at 20 °C, but it is readily miscible with a wide variety of organic solvents including alcohols, esters, ethers, and hydrocarbons.
Stability and reactivity
MIPK is stable under normal storage conditions in tightly closed containers. It is highly flammable and forms explosive vapor–air mixtures at concentrations within its flammability range. Strong oxidizing agents, strong acids, and bases should be avoided, as they may lead to violent reactions. Thermal decomposition or combustion produces hazardous gases including carbon monoxide and carbon dioxide.
Toxicology information
MIPK is classified as a flammable liquid with narcotic effects upon inhalation. Short-term exposure may cause irritation of the eyes, nose, and throat, as well as symptoms such as dizziness, drowsiness, and headache. Prolonged or repeated contact can lead to skin dryness and irritation due to defatting. Ingestion may cause gastrointestinal discomfort and systemic effects. The substance is not classified as carcinogenic but must be handled with care, especially in pharmaceutical and agrochemical applications where strict limits for residual solvents apply.
MIPK is biodegradable and not considered persistent in the environment, but it can be harmful to aquatic organisms due to oxygen depletion and pH changes in high concentrations. Spillage into soil and watercourses should be avoided. Proper disposal and emission controls must be followed in compliance with environmental regulations.